reMAINE Healthy is a unique translational research collaborative that reaches across Maine to tackle one of the top state, national and world health care priorities.

Scientists and physicians from four Maine institutions: The MDI Biological Laboratory, The Jackson Laboratory, Maine Medical Center and its research institution, have partnered together to translate laboratory discoveries in mice and zebrafish into improved therapeutic tools for patients for early diagnosis, treatment or prevention of chronic kidney disease in humans. This novel, collaborative approach is cost effective and has the ability to dramatically increase the speed of discovery.


Knockdown of the Hypertension-Associated Gene NOSTRIN Alters Glomerular Barrier Function in Zebrafish (Danio rerio)

“Zebrafishing” for Novel Genes Relevant to the Glomerular Filtration Barrier

Mutations in the Gene That Encodes the F-Actin Binding Protein Anillin Cause FSGS


In the US chronic kidney disease affects 26 million adults and over $42 billion is spent annually treating patients with the disease.

It is a major diagnostic challenge, as people with early stages of the disease tend not to have any symptoms. The most common causes of kidney disease are hypertension and diabetes.

The Center for Disease Control predicts that 1 in 3 people in the US will develop diabetes by the year 2050

reMAINE Healthy is making important strides in the search to diagnose, treat or prevent chronic kidney disease in humans. The results from this exciting model of translational research could have impacts worldwide.


reMAINE Healthy Featured on MPBN’s Maine Watch

Link to: MPBN Maine Watch Segment

Link to: New York Times Article: Kidney Disease the Underestimated Killer